Download PDF by Peter Greenwald (auth.), Vincenzo Zappia, Fulvio Della: Advances in Nutrition and Cancer 2

By Peter Greenwald (auth.), Vincenzo Zappia, Fulvio Della Ragione, Alfonso Barbarisi, Gian Luigi Russo, Rossano Dello Iacovo (eds.)

ISBN-10: 144193331X

ISBN-13: 9781441933317

ISBN-10: 1475732309

ISBN-13: 9781475732306

This quantity contains contributions awarded on the moment foreign Sym­ posium on nutrients and melanoma, held in Naples, Italy, in October 1998 on the nationwide Tumor Institute "Fondazione Pascale." in the course of the convention, specialists from assorted disciplines mentioned pivotal and well timed matters at the interactions among human food and the advance of malignancies. evaluating the subjects of this assembly with these mentioned on the First Sympo­ sium in 1992, the key medical developments definitely derive from the huge use of molecular methods to accomplish learn in food. furthermore, the elemental commentary of R. Doll and R. Peto (1981), which steered that at the very least 35% of all cancers (with huge variations between various tumors) could be avoided by way of nutritional regimens, has been definitively proven by means of epidemiological experiences. nevertheless, the relationships among nutrition and melanoma are relatively complicated and complicated; it really is tough, and while no longer methodologically right, to lessen them to basic phrases. Metabolic and hormonal components, contaminants and organic brokers, and deficiency of particular protecting nutrition are all items of a similar puzzle.

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S The most * For the full list of EPIC-Italy collaborators see the end of this chapter Advances in Nutrition and Cancer 2, edited by Zappia et al. Kluwer Academic / Plenum Publishers, New York, 1999. 21 22 D. Palli et al. consistent result so far is that a diet rich in vegetables and fruit is associated with lower cancer risk. 6,7,8,9 Various hypotheses have been put forward to explain why consumption of vegetables and fruit is associated with a: reduced risk of cancer. Despite the current difficulty of identifying active anti-carcinogens, the accumulation of epidemiological studies lends strength to the observed association between vegetables and fruit intake and lower cancer risk.

Science. 1987;238:163-170. 65. N. DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. Eur J Cancer Prevention. 1994;3:473-479. 66. Feinberg AP. and Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 1983;301:89-92. 67. , and Feinberg AP. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science. 1985;228:187-190. 68. , and Ehrlich M. Reduced genomic 5-methylcytosine content in human colonic neoplasia.

The major causes Advances in Nutrition and Cancer 2, edited by Zappia et al. Kluwer Academic / Plenum Publishers, New York, 1999. 29 30 E. Giovannucci of upper gastrointestinal tract cancers are likely related to various food practices or preservation methods other than refrigeration, which increase mucosal exposure to irritants or carcinogens. INTRODUCTION The wide variation in incidence and mortality rates for most cancer sites across populations worldwide! indicates that cancer is a disease influenced primarily by external factors.

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Advances in Nutrition and Cancer 2 by Peter Greenwald (auth.), Vincenzo Zappia, Fulvio Della Ragione, Alfonso Barbarisi, Gian Luigi Russo, Rossano Dello Iacovo (eds.)


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